Upstream Bio, Inc. (UPB) short interest & short volume · 15.7% of float short
Upstream Bio, Inc. official short interest (FINRA, twice monthly) and daily short volume (FINRA Reg SHO), with history, % of float and days to cover.
What changed
UPB short interest was little changed at 4.5M shares in the Oct 15, 2026 report (15.7% of float, 3.7 days to cover). Daily short volume averaged 20.0% of volume over the last 20 sessions, down from 39.5% the 20 sessions before, the 0th percentile of its own 20-day averages since Sep 23, 2025.
Short interest
Official, twice monthly · settled Oct 15, 2026
- Shares short
- 4.5M
- prior 4.5M
- % of float
- 15.7%
- float 28.5M
- Days to cover
- 3.7
- avg vol 1.2M
- Change vs prior report
- -0.8%
Days to cover is short interest divided by FINRA's average daily volume for the period: how many average days of trading it would take shorts to buy back.
% of float uses the current float for every report (no float was stored with older reports).
Source: FINRA equity short interest (twice monthly) · Settlement Oct 15, 2026
Daily short volume
Share of each day's volume sold short · FINRA Reg SHO
- Latest (Nov 2)
- 8.3%
- 25K of 299K
- 20-day average
- 20.0%
- prior 39.5%
- Percentile vs own history
- 0th
- 233 periods since 2025
Loading prices…
Source: FINRA Reg SHO daily short sale volume · Latest Nov 2, 2026
Short squeeze score (model)
Price since settlement: +0.6%
Model, not a forecast: 40 pts short interest % of float (full at 30%), 25 pts days to cover (full at 10), 15 pts rise in short interest since the prior report (full at +50%), 20 pts price gain since the settlement date (full at +25%). Missing inputs score 0.
UPB's squeeze score and its inputs with Lician Pro.Start 3-day trial — $149/yr
Market-wide: most shorted stocks, biggest changes and unusual short volume · UPB overview
| Date | Short | Total | Short % of volume |
|---|---|---|---|
| 2026-11-02 | 24,890 | 299,099 | 8.3% |
| 2026-10-30 | 22,253 | 362,331 | 6.1% |
| 2026-10-29 | 87,110 | 429,795 | 20.3% |
| 2026-10-28 | 71,936 | 405,920 | 17.7% |
| 2026-10-27 | 96,585 | 518,350 | 18.6% |
| 2026-10-26 | 133,654 | 442,621 | 30.2% |
| 2026-10-23 | 189,634 | 499,816 | 37.9% |
| 2026-10-22 | 216,045 | 745,363 | 29.0% |
| 2026-10-21 | 135,683 | 538,350 | 25.2% |
| 2026-10-20 | 116,042 | 878,904 | 13.2% |
Healthcare peers with similar quant ratings
UPB is rated 1.21 of 5 among 532 rated Healthcare stocks (Lician quant rating, Nov 4, 2026). How the rating works
- VKTX short interest1.24 · Strong Sell · stock
- RCUS short interest1.23 · Strong Sell · stock
- IMNM short interest1.22 · Strong Sell · stock
- QURE short interest1.21 · Strong Sell · stock
- ELDN short interest1.20 · Strong Sell · stock
- INBX short interest1.19 · Strong Sell · stock
- SRZN short interest1.18 · Strong Sell
- STOK short interest1.18 · Strong Sell · stock
UPB short interest FAQ
What is UPB's short interest?
Upstream Bio, Inc. (UPB) had 4.5M shares sold short and not yet covered in FINRA's Oct 15, 2026 settlement report, 15.7% of its 28.5M-share float.
How many days to cover does UPB have?
3.7 days: 4.5M shares short divided by an average daily volume of 1.2M for the Oct 15, 2026 period.
Is UPB short interest rising or falling?
UPB short interest was little changed (-0.8%) from 4.5M to 4.5M shares in the Oct 15, 2026 report.
Is UPB a short squeeze candidate?
Lician's squeeze watch scores UPB 31 out of 100 (low) from the Oct 15, 2026 report: short interest % of float 21/40, days to cover 9.2/25, change in short interest vs prior report 0/15, price change since settlement date 0.5/20. It is a transparent model of how crowded the short side is, not a forecast that a squeeze will happen.
What share of UPB daily volume is sold short?
20.0% on average over the last 20 sessions to Nov 2, 2026 (FINRA Reg SHO daily short volume; the 0th percentile of its own 20-day averages). Short volume counts market makers' same-day short sales, so it is not short interest.
What was UPB's latest FINRA short volume?
On Nov 2, 2026, cached FINRA short volume for Upstream Bio, Inc. (UPB) was 24,890 shares, 8.3% of 299,099 total volume.
How many UPB short-volume sessions are listed on this page?
This page lists 10 cached FINRA short-volume sessions for Upstream Bio, Inc. (UPB), from Oct 20, 2026 through Nov 2, 2026.
How did UPB short volume percent change from the prior cached session?
Cached FINRA short volume for Upstream Bio, Inc. (UPB) moved from 6.1% on Oct 30, 2026 to 8.3% on Nov 2, 2026, up 2.2 percentage points.
Not investment advice. Figures as filed or reported, not a live feed.