Spyre Therapeutics Inc. (SYRE) short interest & short volume · 12.5M shares short
Spyre Therapeutics Inc. official short interest (FINRA, twice monthly) and daily short volume (FINRA Reg SHO), with history, % of float and days to cover.
What changed
SYRE short interest fell 2.6% to 12.5M shares in the Oct 15, 2026 report (7.3 days to cover). Daily short volume averaged 62.3% of volume over the last 20 sessions, the 54th percentile of its own 20-day averages since Sep 23, 2025.
Short interest
Official, twice monthly · settled Oct 15, 2026
- Shares short
- 12.5M
- prior 12.8M
- % of float
- —
- no float on file
- Days to cover
- 7.3
- avg vol 1.7M
- Change vs prior report
- -2.6%
Days to cover is short interest divided by FINRA's average daily volume for the period: how many average days of trading it would take shorts to buy back.
Source: FINRA equity short interest (twice monthly) · Settlement Oct 15, 2026
Daily short volume
Share of each day's volume sold short · FINRA Reg SHO
- Latest (Nov 2)
- 76.8%
- 196K of 255K
- 20-day average
- 62.3%
- prior 61.8%
- Percentile vs own history
- 54th
- 233 periods since 2025
Loading prices…
Source: FINRA Reg SHO daily short sale volume · Latest Nov 2, 2026
Short squeeze score (model)
Price since settlement: +23.9%
Model, not a forecast: 40 pts short interest % of float (full at 30%), 25 pts days to cover (full at 10), 15 pts rise in short interest since the prior report (full at +50%), 20 pts price gain since the settlement date (full at +25%). Missing inputs score 0.
SYRE's squeeze score and its inputs with Lician Pro.Start 3-day trial — $149/yr
Market-wide: most shorted stocks, biggest changes and unusual short volume · SYRE overview
| Date | Short | Total | Short % of volume |
|---|---|---|---|
| 2026-11-02 | 195,933 | 255,251 | 76.8% |
| 2026-10-30 | 169,093 | 284,967 | 59.3% |
| 2026-10-29 | 110,180 | 203,352 | 54.2% |
| 2026-10-28 | 191,493 | 288,023 | 66.5% |
| 2026-10-27 | 268,742 | 434,940 | 61.8% |
| 2026-10-26 | 196,643 | 309,409 | 63.5% |
| 2026-10-23 | 150,737 | 185,682 | 81.2% |
| 2026-10-22 | 149,873 | 228,465 | 65.6% |
| 2026-10-21 | 180,394 | 300,766 | 60.0% |
| 2026-10-20 | 435,258 | 645,926 | 67.4% |
Healthcare peers with similar quant ratings
SYRE is rated 2.69 of 5 among 532 rated Healthcare stocks (Lician quant rating, Nov 4, 2026). How the rating works
- AZTA short interest2.72 · Hold · stock
- COLL short interest2.71 · Hold · stock
- CTEV short interest2.70 · Hold · stock
- DNLI short interest2.70 · Hold · stock
- BBNX short interest2.68 · Hold · stock
- DNTH short interest2.67 · Hold · stock
- SRPT short interest2.67 · Hold · stock
- SI short interest2.66 · Hold · stock
SYRE short interest FAQ
What is SYRE's short interest?
Spyre Therapeutics Inc. (SYRE) had 12.5M shares sold short and not yet covered in FINRA's Oct 15, 2026 settlement report.
How many days to cover does SYRE have?
7.3 days: 12.5M shares short divided by an average daily volume of 1.7M for the Oct 15, 2026 period.
Is SYRE short interest rising or falling?
SYRE short interest fell (-2.6%) from 12.8M to 12.5M shares in the Oct 15, 2026 report.
Is SYRE a short squeeze candidate?
Lician's squeeze watch scores SYRE 38 out of 100 (low) from the Oct 15, 2026 report: days to cover 18.4/25, change in short interest vs prior report 0/15, price change since settlement date 19.1/20. It is a transparent model of how crowded the short side is, not a forecast that a squeeze will happen.
What share of SYRE daily volume is sold short?
62.3% on average over the last 20 sessions to Nov 2, 2026 (FINRA Reg SHO daily short volume; the 54th percentile of its own 20-day averages). Short volume counts market makers' same-day short sales, so it is not short interest.
What was SYRE's latest FINRA short volume?
On Nov 2, 2026, cached FINRA short volume for Spyre Therapeutics Inc. (SYRE) was 195,933 shares, 76.8% of 255,251 total volume.
How many SYRE short-volume sessions are listed on this page?
This page lists 10 cached FINRA short-volume sessions for Spyre Therapeutics Inc. (SYRE), from Oct 20, 2026 through Nov 2, 2026.
How did SYRE short volume percent change from the prior cached session?
Cached FINRA short volume for Spyre Therapeutics Inc. (SYRE) moved from 59.3% on Oct 30, 2026 to 76.8% on Nov 2, 2026, up 17.5 percentage points.
Not investment advice. Figures as filed or reported, not a live feed.